Today we have a rockstar physician with us. We will discuss diabetes with her.
Classification of Diabetes Mellitus – Diabetes Lecture – 4 Type 1 Diabetes Beta cell destruction, usually leading to absolute insulin deficiency Type 2 Diabetes Combination of insulin resistance and beta cell dysfunction Genetic Defects of Beta Cell Function Maturity-onset diabetes of the young (MODY), caused by mutations in: Hepatocyte nuclear factor 4α gene (HNF4A)—MODY1 Glucokinase gene (GCK)—MODY2 Hepatocyte nuclear factor 1α gene (HNF1A)—MODY3 Pancreatic and duodenal homeobox 1 gene (PDX1)—MODY4 Hepatocyte nuclear factor 1β gene (HNF1B)—MODY5 Neurogenic differentiation factor 1 gene (NEUROD1)—MODY6 Maternally inherited diabetes and deafness (MIDD) due to mitochondrial DNA mutations (3243A→G) Defects in proinsulin conversion Insulin gene mutations Genetic Defects in Insulin Action Insulin receptor mutations Exocrine Pancreatic Defects Chronic pancreatitis Pancreatectomy Neoplasia Cystic fibrosis Hemochromatosis Fibrocalculous pancreatopathy Endocrinopathies Growth hormone excess (acromegaly) Cushing syndrome Hyperthyroidism Pheochromocytoma Glucagonoma Infections Cytomegalovirus infection Coxsackievirus B infection Congenital rubella Drugs Glucocorticoids Thyroid hormone β-Adrenergic agonists Genetic Syndromes Associated with Diabetes Down syndrome Klinefelter syndrome Turner syndrome Gestational Diabetes Mellitus